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The corticospinal and rubrospinal systems function in skilled movement control. A key question is how do these develop the capacity to coordinate their motor functions and, turn, if red nucleus/rubrospinal tract (RN/RST) compensates for developmental injury? We used cat investigate whether developing system shaped by activity-dependent interactions with system. unilaterally inactivated M1 muscimol microinfusion between postnatal weeks 5 7 examine RN/RST (CST) impairments CST misprojections after inactivation. examined RN map RST cervical projections at of age, while was inactivated, 14 weeks, activity returned. During inactivation, on same side showed normal reduced thresholds, suggestive precocious development. By contrast, untreated/active sparse an immature map. After returned later adolescent development, active M1/CST continued show a substantial loss spinal terminations impaired regressed smaller fewer axons. Our findings suggest that under regulation establishing mature connections lack RS compensation non-inactivated can be explained development ipsilateral from outcompete RST. SIGNIFICANCE STATEMENT Skilled movements reflect multiple descending circuits. Currently, there little insight into interact during emerging so, mechanisms underlying this process. This study systems, two limb movements. competes nucleus connections. first demonstration one steering ultimately function, another. Knowledge competition helps predict response following injury.